Description
What is 5-Amino-1MQ?
5-Amino-1MQ is a small molecule inhibitor of the enzyme Nicotinamide N-methyltransferase (NNMT). Initially developed as a potential therapeutic for metabolic disorders, it has gained significant attention for its ability to increase intracellular NAD+ levels, enhance energy metabolism, and promote fat loss while preserving lean muscle mass. Its mechanism of action—blocking the methylation of nicotinamide—positions it as a powerful tool in metabolic research and a compound of high interest in the fields of longevity, obesity, and athletic performance.
Physiological Benefits
- ✔Reduces Adiposity and Promotes Fat Loss: The most well-documented benefit. Mouse studies show a significant reduction in white adipose tissue mass and prevention of diet-induced obesity.
- ✔Preserves Lean Muscle Mass: Unlike many weight loss interventions that cause muscle catabolism, 5-Amino-1MQ appears to specifically target fat stores while sparing or even promoting skeletal muscle health.
- ✔Increases Basal Metabolic Rate: By boosting cellular NAD+ and mitochondrial function, it elevates energy expenditure, leading to greater calorie burn throughout the day.
- ✔Improves Insulin Sensitivity: By reducing fat accumulation and improving cellular metabolism, it helps cells respond more effectively to insulin, a key factor in preventing type 2 diabetes.
- ✔Lowers Cholesterol Levels: Animal studies consistently show a reduction in total and LDL cholesterol, likely due to improved hepatic lipid metabolism.
- ✔Supports Liver Health: Shows potential in reversing or preventing non-alcoholic fatty liver disease (NAFLD) by reducing hepatic fat accumulation (steatosis).
- ✔Enhances Cellular Energy and Endurance: The increase in NAD+ directly fuels mitochondrial energy production, which may translate to improved physical stamina and reduced fatigue.
- ✔Potential Anti-Aging Effects: Through the activation of NAD+-dependent sirtuins, 5-Amino-1MQ may help mitigate age-related cellular decline, improve DNA repair, and promote longevity.
- ✔Potential Neuroprotective Properties: NAD+ is critical for neuronal health. By boosting NAD+ levels in the brain, 5-Amino-1MQ is being investigated for its potential to protect against age-related cognitive decline.
- ✔May Improve Cellular Repair Processes: NAD+ is essential for the function of PARPs, enzymes that are critical for repairing damaged DNA.
Use Cases
Its primary investigated use case is as a pharmacological tool to induce fat loss and prevent weight gain, particularly in the context of a high-calorie diet.
For athletes and bodybuilders looking to reduce body fat while maintaining or building muscle mass during a cutting phase.
To address multiple facets of metabolic syndrome simultaneously, including obesity, insulin resistance, and dyslipidemia.
As an adjunct therapy to improve glycemic control and insulin sensitivity.
Used within a broader strategy to boost NAD+ levels, activate sirtuins, and combat age-related metabolic slowdown.
As a targeted therapy to reduce the accumulation of fat in the liver.
To enhance mitochondrial efficiency and energy production, potentially leading to improved stamina and recovery.
Investigated for its potential to support brain energy metabolism and protect against neurodegeneration.
May synergize with ketogenic diets by further enhancing fat oxidation and metabolic flexibility.
Common Research Protocols
⚠ Research Use Only
The following data is for educational purposes only. Lanna Peptides compounds are not for human consumption.
| Route | Typical Dosage Range (for Research) | Frequency | Notes / Cycle Information | |
|---|---|---|---|---|
| Subcutaneous (SubQ) | 20 – 50 mg per day | Once daily | Administered daily. Subcutaneous delivery provides a direct route of administration, bypassing first-pass metabolism to maximize potential system uptake. |
Need more technical data?
For a comprehensive analysis including Mechanism of Action, Chemical Structure, Pharmacokinetics, and complete Safety Profile, click the button below to review the full Clinical Summary of 5-Amino-1MQ.
Reviews
There are no reviews yet.