Description
What is BPC-157?
Body Protection Compound 157 (BPC-157) is a synthetic pentadecapeptide composed of 15 amino acids. Derived from a protein found in human gastric juice, it has demonstrated significant cytoprotective and regenerative properties across a wide range of preclinical studies. Initially investigated for its gastroprotective effects, its therapeutic potential has expanded to include accelerated healing of musculoskeletal tissues, neuroprotection, and modulation of inflammatory and vascular processes.
Synergy Note: This peptide is frequently stacked with TB-500. When used together, they may offer a synergistic effect, potentially accelerating the repair of muscles, tendons, and ligaments more effectively than either compound alone.
Physiological Benefits
- ✔Accelerated Musculoskeletal Healing: Dramatically speeds up the repair of tendons, ligaments, muscles, and bones. Studies show superior collagen organization and increased tensile strength in healed tissues.
- ✔Gastrointestinal Protection and Repair: Heals gastric and intestinal ulcers, counteracts damage from NSAIDs and alcohol, and shows efficacy in animal models of IBD (Crohn’s, Ulcerative Colitis) and “leaky gut” syndrome.
- ✔Potent Anti-Inflammatory Action: Modulates inflammatory pathways to reduce swelling and pain associated with injury and chronic conditions, without the side effects of corticosteroids or NSAIDs.
- ✔Neuroprotection and Central Nervous System Repair: Protects neurons from ischemic damage, promotes functional recovery after spinal cord injury, and mitigates symptoms in models of Parkinson’s disease and TBI.
- ✔Cardioprotective Effects: Protects the heart from ischemia-reperfusion injury, helps maintain blood pressure homeostasis, and can correct arrhythmias in animal models.
- ✔Wound and Skin Healing: Accelerates the healing of skin incisions, burns, and diabetic ulcers by promoting angiogenesis and granulation tissue formation.
- ✔Organo-protection: Demonstrates protective effects on the liver, pancreas, and kidneys against various toxins and insults.
- ✔Reversal of Drug-Induced Damage: Has been shown to counteract the systemic side effects of drugs like corticosteroids (e.g., muscle wasting) and antipsychotics (e.g., catalepsy).
- ✔Pain Reduction: Exhibits analgesic properties, reducing pain at the site of injury, likely through a combination of anti-inflammatory action and modulation of pain signaling pathways.
- ✔Enhanced Post-Surgical Recovery: Anecdotal and preclinical evidence suggests it can significantly reduce recovery time and improve outcomes after surgical procedures by promoting faster tissue integration and reducing inflammation.
Use Cases
For chronic injuries like tennis elbow, golfer’s elbow, or Achilles tendinosis. SubQ injection near the site is the most common application.
To accelerate healing of partially torn ligaments, such as the ACL, MCL, or ankle ligaments.
To speed up recovery from acute muscle injuries, reducing hematoma formation and promoting faster regeneration of muscle fibers.
Administered after orthopedic surgeries (e.g., rotator cuff repair, ACL reconstruction) to enhance graft integration and reduce recovery time.
Oral administration of stable BPC-157 (Arginate salt) is used to target inflammation and mucosal healing in Crohn’s disease and ulcerative colitis.
Oral use to protect the gastric mucosa from NSAID-induced damage and promote the healing of existing ulcers.
Intranasal or systemic administration is being researched for its neuroprotective and restorative effects following head trauma.
Used to promote regeneration and functional recovery after peripheral nerve injury (e.g., carpal tunnel syndrome, sciatica).
Injected systemically or near affected joints to reduce inflammation and pain associated with osteoarthritis and rheumatoid arthritis.
Used systemically via SubQ injection by athletes to improve recovery between intense training sessions and mitigate the wear-and-tear on joints and soft tissues.
Applied topically in a cream or gel formulation to accelerate the healing of severe burns or non-healing ulcers.
Administered to mitigate the catabolic effects of long-term corticosteroid use, such as muscle wasting and impaired healing.
Common Research Protocols
⚠ Research Use Only
The following data is for educational purposes only. Lanna Peptides compounds are not for human consumption.
| Route | Typical Dosage Range | Frequency | Notes | |
|---|---|---|---|---|
| Subcutaneous (SubQ) | 250 – 750 mcg per day | Once or twice daily | Most common method. Often injected near the site of injury (e.g., abdomen for systemic effect, shoulder for rotator cuff). Dosages often calculated at 2-10 mcg/kg. | |
| Intramuscular (IM) | 250 – 500 mcg per injection | Once daily | Used for deep muscle injuries. May offer more targeted delivery but is often unnecessary as SubQ provides systemic effects. |
Need more technical data?
For a comprehensive analysis including Mechanism of Action, Chemical Structure, Pharmacokinetics, and complete Safety Profile, click the button below to review the full Clinical Summary of BPC-157.
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