Description
What is MOTS-c?
MOTS-c (Mitochondrial Open Reading Frame of the 12S rRNA-c) is a peptide encoded in the mitochondrial genome that acts as a potent regulator of metabolic homeostasis. It functions primarily by activating the AMPK pathway, mimicking the cellular effects of exercise. Research demonstrates its ability to enhance insulin sensitivity, prevent diet-induced obesity, and improve physical endurance. As an “exercise mimetic,” it offers hope for treating metabolic syndrome and age-related metabolic decline.
Physiological Benefits
- ✔Enhanced Insulin Sensitivity & Glucose Homeostasis: Reverses diet-induced and age-dependent insulin resistance, making it a strong candidate for managing pre-diabetes and Type 2 Diabetes.
- ✔Increased Fatty Acid Oxidation & Weight Management: Promotes the burning of fat for energy and prevents fat accumulation, particularly in the liver, aiding in weight management and combating obesity and NAFLD.
- ✔Improved Physical Performance & Endurance: By mimicking the metabolic effects of exercise, it increases exercise capacity, endurance, and physical resilience, as demonstrated in animal models.
- ✔Skeletal Muscle Remodeling & Function: Promotes metabolic adaptation in skeletal muscle, improving function and counteracting age-related muscle decline (sarcopenia) and frailty.
- ✔Neuroprotection & Cognitive Enhancement: Crosses the blood-brain barrier and has been shown in preclinical models to protect neurons from metabolic and toxic insults, with potential applications in Alzheimer’s and Parkinson’s disease.
- ✔Cardioprotective Effects: Protects cardiac cells from ischemic injury (heart attack), reduces cardiac fibrosis, and improves overall cardiovascular function by optimizing cellular metabolism.
- ✔Anti-Fibrotic Properties: Actively inhibits the development of fibrotic tissue in multiple organs, offering therapeutic potential for conditions like liver cirrhosis, pulmonary fibrosis, and heart failure.
- ✔Regulation of Bone Health: Modulates the balance between osteoblasts (bone-building cells) and osteoclasts (bone-resorbing cells), promoting bone formation and potentially treating osteoporosis.
- ✔Anti-inflammatory Effects: Systemically reduces chronic, low-grade inflammation, a key driver of most age-related diseases.
- ✔Longevity & Anti-Aging Potential: By improving mitochondrial function, reducing oxidative stress, and regulating metabolism, MOTS-c targets several core hallmarks of aging, extending healthspan in animal models.
Use Cases
As a primary therapy or adjunct to improve insulin sensitivity and glucose control.
To enhance fat metabolism, prevent fat storage, and improve body composition, especially in individuals with metabolic resistance.
Used by athletes to boost endurance, improve metabolic efficiency during exercise, and accelerate recovery.
To preserve muscle mass, improve physical function, and increase resilience in the elderly.
To reduce liver fat accumulation, inflammation, and fibrosis. This is a leading area of clinical research.
As a protective agent to mitigate damage from a heart attack and prevent pathological remodeling of the heart.
Employed in anti-aging protocols to enhance mitochondrial health, reduce systemic inflammation, and improve overall vitality.
Investigated as a potential therapy to slow the progression of diseases like Alzheimer’s by improving brain cell metabolism and resilience.
To shift bone remodeling in favor of bone formation.
Early research suggests it may mitigate some side effects of chemotherapy, such as cisplatin-induced kidney injury, by protecting healthy cells.
Common Research Protocols
⚠ Research Use Only
The following data is for educational purposes only. Lanna Peptides compounds are not for human consumption.
| Route | Typical Dosage (Research) | Frequency | Notes / Cycle Example | |
|---|---|---|---|---|
| Subcutaneous (SubQ) | 5 mg – 15 mg per week | Dosed 2-3 times per week (e.g., 5mg on Mon/Thurs) or as a single weekly injection. | Metabolic Cycle: 10mg per week (split into two 5mg injections) for 4-8 weeks, followed by a 4-week washout period. | |
| Intramuscular (IM) | 5 mg – 10 mg per injection | 2-3 times per week. | Less common than SubQ. May offer slightly faster absorption but is generally not preferred for systemic peptides. |
Need more technical data?
For a comprehensive analysis including Mechanism of Action, Chemical Structure, Pharmacokinetics, and complete Safety Profile, click the button below to review the full Clinical Summary of MOTS-c.
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